Vismodegib CAS 879085-55-9

Produkt beskrivelse:

Produktnavn: Vismodegib CAS 879085-55-9

 

Synonymer:

2-Chlor-N-[4-chlor-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamid;BROM-1-NAPHTA

BenzaMide, 2-chlor-N-[4-chlor-3-(2-pyridinyl)phenyl]-4-(Methylsulfonyl)-;

VisModegib (GDC-0449);

 

Kemiske og fysiske egenskaber

Udseende: Hvid til råhvid fast

Analyse: 99%+

Kogepunkt: 561,6±50,0 grader

Smeltepunkt:179-181 grad

Molekylvægt: 421,3

Densitet: 1,440

Pka:10.72±0.70

Stabilitet: Stabil i 2 år fra købsdato som leveret. Opløsninger i DMSO eller ethanol kan opbevares ved -20 grad i op til 3 måneder.

 

Ansøgning:

Vimodej targets SMO protein and inhibits Gli activation, thereby inhibiting downstream gene transcription and expression.For the treatment of locally progressive or metastatic basal cell carcinoma in adults who have recurred after surgery or are not well treated with surgery or radiotherapy; One of the most common skin cancers is basal cell carcinoma (BCC), which originates in the surface layer of the skin and does not cause pain to patients. The risk was greatest for skin diseases that were regularly exposed to the sun or ultraviolet light. The development and listing of Vimedji has brought good news to patients with BCC, and its clinical role is important and the target market is huge, and it has to grow into a "giant bomb" class (>$1 milliard) lægemiddel i fremtiden.

 

 

 

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